Traumatic brain injury (TBI) trials require comprehensive, high-resolution data management, but past efforts have struggled with synchronization, metadata tracking, and centralized storage. The CONNECT platform addresses these gaps by providing a cloud-based, de-identified data repository with real-time management and analysis tools. Data are harmonized into HDF5 format, synchronized with electronic medical records (EMRs), and stored on IBM Cloud with AWS S3 access. CONNECT supports secure data uploads, open-source API access, and quality assurance workflows. Successfully tested in BOOST-3 and TRACK-TBI, the platform will be deployed in PRECICECAP and ELECTRO-BOOST. Future work includes broader validation, austere environment applications, and automated trial data review.